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Comparative Study
. 2000 Jan-Feb;24(1):61-6.
doi: 10.1097/00004728-200001000-00013.

Focal nodular hyperplasia: natural course observed with CT and MRI

I Leconte  1 , B E Van Beers, M Lacrosse, C Sempoux, J Jamart, R Materne, V Baudrez, Y Horsmans
Affiliations
Comparative Study

Focal nodular hyperplasia: natural course observed with CT and MRI

I Leconte et al. J Comput Assist Tomogr. 2000 Jan-Feb.

Abstract

Purpose: The purpose of this work was to assess the natural course of biopsy-proven focal nodular hyperplasia (FNH).

Method: Eighteen biopsy-proven FNHs in 14 patients (12 women and 2 men) who were followed for at least 6 months with CT and/or MRI were included in the study. The volume of the lesions was calculated twice by two observers using the summation of areas method. Intra- and interobserver variability was assessed by intraclass correlation coefficients. Longitudinal data analysis was performed with generalized estimating equations.

Results: The volume of FNH was stable in 6 cases, decreased in 10 cases, and increased in 2 cases. Intra- and interobserver variability in size measurements was 5-10%. Intraclass correlation coefficients were >0.992. Longitudinal data analysis showed that there was a general trend of lesion regression.

Conclusion: Long-term follow-up and objective measurements performed in patients with biopsy-proven lesions show that the natural course of FNH is variable. In particular, lesion regression is not rare.

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