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Case Reports
. 2000 Jan;7(1):54-7.
doi: 10.1016/s0929-693x(00)88918-6.

[(P)FAPA syndrome: value of cimetidine]

[Article in French]
P Pillet  1 , S Ansoborlo, A Carrère, Y Perel, J M Guillard
Affiliations
Case Reports

[(P)FAPA syndrome: value of cimetidine]

[Article in French]
P Pillet et al. Arch Pediatr. 2000 Jan.

Abstract

The (P)FAPA syndrome (periodic fever, adenitidis, pharyngitis, aphthous stomatitis) was described in 1987. The etiology of this periodic syndrome remains unknown. We report three new cases.

Case reports: Three girls, aged from 23 months to eight years, developed (P)FAPA. The other causes of periodic fevers were eliminated and the various treatments (antibiotics, antipyretics, nonsteroidal anti-inflammatory agents) proved ineffective. The repetition of the periodic bouts resulted in depressive disorders, absenteeism from school and a drop in weight in the youngest patient. Two of them suffered a sinusal involvement (chronic sinusitis, polyp) and had an increase in the level of immunoglobulin A. In all three cases, cimetidine at a dose of 20 mg/kg/d was well tolerated and resulted in a disappearance of the periodic fevers.

Conclusion: Cimetidine, as an immunomodulating agent, appears to be beneficial in the in-depth treatment of (P)FAPA syndrome.

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Comment in

  • [FPAPA syndrome].
    Hayem F. Hayem F. Arch Pediatr. 2000 Aug;7(8):898. doi: 10.1016/s0929-693x(00)80207-9. Arch Pediatr. 2000. PMID: 10985197 French. No abstract available.

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