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Review
. 2000 Feb;105(2 Pt 2):S487-92.
doi: 10.1016/s0091-6749(00)90048-4.

The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma

S B Liggett  1
Affiliations
Review

The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma

S B Liggett. J Allergy Clin Immunol. 2000 Feb.

Abstract

The beta(2)-adrenergic receptor (beta(2)AR) is the molecular target for beta-agonists used in the treatment of asthma. In the human population, 4 polymorphisms of the beta(2)AR coding block have been found, 3 of which result in receptors that have different properties compared with wild-type. To date, clinical studies suggest that these beta(2)AR polymorphisms may alter asthmatic phenotype and the response to beta-agonist therapy, making these variants the first of undoubtedly several genetic loci that will ultimately be found that will provide for individualized therapy in asthma.

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