Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Feb;105(2 Pt 2):S547-58.
doi: 10.1016/s0091-6749(00)90059-9.

Molecular mechanisms of IgE regulation

L B Bacharier  1 , R S Geha
Affiliations
Review

Molecular mechanisms of IgE regulation

L B Bacharier et al. J Allergy Clin Immunol. 2000 Feb.

Abstract

IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cepsilon gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response.

PubMed Disclaimer

Publication types

LinkOut - more resources