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Comparative Study
. 2000 Mar-Apr;46(2):135-42.
doi: 10.1159/000007268.

In vitro effects of meropenem and imipenem/cilastatin on some functions of human natural effector cells

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Comparative Study

In vitro effects of meropenem and imipenem/cilastatin on some functions of human natural effector cells

P Cornacchione et al. Chemotherapy. 2000 Mar-Apr.

Abstract

Meropenem, a new carbapenem antibiotic, was assessed to evaluate its effects on some functional parameters of human polymorphonuclear (PMN) and natural killer (NK) cells in comparison with imipenem/cilastatin. Both drugs significantly inhibited PMN phagocytosis and chemotaxis at concentrations of 2,000 and 4,000 microg/ml. They affected PMN microbicidal activity, evaluated against Candida albicans, only at 4,000 microg/ml. A study of the effects of both drugs on peripheral NK populations and the human NK line (NK-92) showed that even at 4,000 microg/ml there was no effect on antitumor activity. These data indicate that meropenem can reduce some PMN antimicrobial functions only at very high concentrations like imipenem/cilastatin, whereas no concentration influenced NK activity.

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