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Clinical Trial
. 1999 Dec;61(6):964-7.
doi: 10.4269/ajtmh.1999.61.964.

No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine

M van Vugt  1 , F Ezzet, F Nosten, I Gathmann, P Wilairatana, S Looareesuwan, N J White
Affiliations
Clinical Trial

No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine

M van Vugt et al. Am J Trop Med Hyg. 1999 Dec.

Abstract

Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses.

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