doi: 10.1073/pnas.73.9.2959.
A possible conformation for double-stranded polynucleotides
- PMID: 1067594
- PMCID: PMC430891
- DOI: 10.1073/pnas.73.9.2959
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A possible conformation for double-stranded polynucleotides
Proc Natl Acad Sci U S A.
1976 Sep.
Abstract
A model is presented for double-stranded polynucleotides which involves side-by-side meshing of the two strands rather than double helical intertwining. The sugar-phosphate backbone has a twisted strip-like character, yet base-pairing of the Watson-Crick type is still possible. Structural features of the basic model are described and coordinates are presented for a representative example. The structure has, on the whole, reasonable sterochemical contacts, and can be shown to produce a fiber diffraction pattern with x-rays not unlike that of the B form of DNA.
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