Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Sep;73(9):3010-4.
doi: 10.1073/pnas.73.9.3010.

Model studies of enzymatic NH2-terminal acetylation of porteins with des-Nalpha1-acetyl-alpha-melanotropin as a substrate

M Granger, G I Tesser, W W De Jong, H Bloemendal

Model studies of enzymatic NH2-terminal acetylation of porteins with des-Nalpha1-acetyl-alpha-melanotropin as a substrate

M Granger et al. Proc Natl Acad Sci U S A. 1976 Sep.

Abstract

The present study describes the acetylation by an enzyme present in calf lens of a synthetic tridecapeptide [analogous to alpha-melanotropin (alpha-melanocyte stimulating hormone) but lacking the naturally occurring NH2-terminal acetyl group: des-Nalpha1-Ac-alpha-melanotropin]. The reaction is specific for the alpha-amino group of the NH2-terminal amino acid. The minimum length required for the substrate to become acetylated appears to be a sequence of five to eight amino acid residues. Modification of the internal lysine decreases the incorporation of acetate, irrespective of the size of the blocking group.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Biochem. 1965 Feb;57:176-83 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Biochim Biophys Acta. 1969 Feb 4;175(1):211-3 - PubMed
    1. Nat New Biol. 1972 Mar 1;236(61):7-9 - PubMed
    1. Biochem J. 1974 Feb;137(2):355-62 - PubMed

LinkOut - more resources