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. 1976 Sep;73(9):3045-9.
doi: 10.1073/pnas.73.9.3045.

Influenza virus genome consists of eight distinct RNA species

D McGeoch, P Fellner, C Newton

Influenza virus genome consists of eight distinct RNA species

D McGeoch et al. Proc Natl Acad Sci U S A. 1976 Sep.

Abstract

The genomic RNA of the avian influenza A virus, fowl plague, was fractionated into eight species by electrophoresis in polyacrylamide-agarose gels containing 6 M urea. The separated 32P-labeled RNA species were characterized by digestion with RNase T1 and fractionation of the resulting oligonucleotides by two-dimensional gel electrophoresis; this demonstrated that each species has a distinct nucleotide sequence. A tentative correlation of each genome RNA species with the virus protein that it encodes was made.

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