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. 1976 Sep;73(9):3165-7.
doi: 10.1073/pnas.73.9.3165.

Tolerance and dependence evoked by an endogenous opiate peptide

A Lampert, M Nirenberg, W A Klee

Tolerance and dependence evoked by an endogenous opiate peptide

A Lampert et al. Proc Natl Acad Sci U S A. 1976 Sep.

Abstract

Incubation of neuroblastoma X glioma hybrid cells for 12-97 hr with methionine-enkephalin results in an increase in adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] that is mediated by the opiate receptor. The results show that cells become tolerant to, and dependent upon, enkephalin.

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References

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    1. Life Sci. 1975 Jun 15;16(12):1759-64 - PubMed
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    1. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3092-6 - PubMed
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