doi: 10.1073/pnas.73.9.3165.
Tolerance and dependence evoked by an endogenous opiate peptide
- PMID: 1067610
- PMCID: PMC430968
- DOI: 10.1073/pnas.73.9.3165
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Tolerance and dependence evoked by an endogenous opiate peptide
Proc Natl Acad Sci U S A.
1976 Sep.
Abstract
Incubation of neuroblastoma X glioma hybrid cells for 12-97 hr with methionine-enkephalin results in an increase in adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] that is mediated by the opiate receptor. The results show that cells become tolerant to, and dependent upon, enkephalin.
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