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. 2000 Mar;68(3):1620-5.
doi: 10.1128/IAI.68.3.1620-1625.2000.

Genetic resistance to experimental infection with Mycobacterium bovis in red deer (Cervus elaphus)

C G Mackintosh  1 , T Qureshi, K Waldrup, R E Labes, K G Dodds, J F Griffin
Affiliations

Genetic resistance to experimental infection with Mycobacterium bovis in red deer (Cervus elaphus)

C G Mackintosh et al. Infect Immun. 2000 Mar.

Abstract

Tuberculosis (Tb) caused by Mycobacterium bovis is a worldwide threat to livestock and humans. One control strategy is to breed livestock that are more resistant to Mycobacterium bovis. In a 3-year heritability study 6 farmed red deer stags were selected from 39 on the basis of their differing responses to experimental challenge via the tonsillar sac with approximately 500 CFU of M. bovis. Two stags remained uninfected, two were moderately affected, and two developed serious spreading Tb. Seventy offspring, bred from these six stags by artificial insemination using stored semen, were similarly challenged with M. bovis. The offspring showed patterns of response to M. bovis challenge similar to those of their sires, providing evidence for a strong genetic basis to resistance to Tb, with an estimated heritability of 0.48 (standard error, 0.096; P < 0. 01). This is the first time the heritability of Tb resistance in domestic livestock has been measured. The breeding of selection lines of resistant and susceptible deer will provide an ideal model to study the mechanisms of Tb resistance in a ruminant and could provide an additional strategy for reducing the number and severity of outbreaks of Tb in farmed deer herds. Laboratory studies to identify genetic and immunological markers for resistance to Tb are under way. Preliminary studies showed no associations between NRAMP or DRB genes and resistance to Tb in deer. Patterns of immune responses seen in resistant animals suggest that both innate and acquired pathways of immunity are necessary to produce the resistant phenotype.

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Figures

FIG. 1
FIG. 1
Relationship between bovine skin test reactivity and LSS for 39 stags challenged with virulent M. bovis. Regression equation, skin thickness = 8.3(+/−1.45) + 0.893(+/−0.424)LSS.
FIG. 2
FIG. 2
Relationship between bovine skin test reactivity and LSS for 69 yearling red deer challenged with virulent M. bovis. Regression equation, skin thickness =3.389(+/−0.671) + 0.868(+/−0.253)LSS.
See this image and copyright information in PMC

References

    1. Abel L, Dessein A J. The impact of host genetics on susceptibility to human infectious diseases. Curr Opin Immunol. 1997;9:509–516. - PubMed
    1. Animal Health Board. Annual report for the year ending 30 June 1998. Wellington, New Zealand: Animal Health Board; 1998.
    1. Asher G W, Fisher M W, Fennessy P F, Mackintosh C G, Jabbour H N, Morrow C J. Oestrus synchronization, semen collection and artificial insemination of farmed red deer (Cervus elaphus) and fallow deer (Dama dama) Anim Reprod Sci. 1993;33:241–265.
    1. Beatson N S, Hutton J B, De Lisle G W. Tuberculosis—test and slaughter. Proc Deer Branch NZVA. 1984;1:18–27.
    1. Collins D M, De Lisle G W. DNA restriction endonuclease analysis of Mycobacterium bovis and other members of the tuberculosis complex. J Clin Microbiol. 1985;21:562–564. - PMC - PubMed

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