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Review
. 2000 Feb;12(1):104-12.
doi: 10.1016/s0955-0674(99)00063-0.

Actin machinery: pushing the envelope

G G Borisy  1 , T M Svitkina
Affiliations
Review

Actin machinery: pushing the envelope

G G Borisy et al. Curr Opin Cell Biol. 2000 Feb.

Abstract

The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility.

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