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Review
. 2000 Feb;10(1):94-9.
doi: 10.1016/s0959-437x(99)00038-6.

The ARF/p53 pathway

C J Sherr  1 , J D Weber
Affiliations
Review

The ARF/p53 pathway

C J Sherr et al. Curr Opin Genet Dev. 2000 Feb.

Abstract

The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

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