Review
doi: 10.1016/s0959-437x(99)00040-4.
Complexity in the spindle checkpoint
Affiliations
- PMID: 10679385
- DOI: 10.1016/s0959-437x(99)00040-4
Item in Clipboard
Review
Complexity in the spindle checkpoint
Curr Opin Genet Dev.
2000 Feb.
Abstract
Cell viability requires accurate chromosome segregation at mitosis. The spindle checkpoint ensures that anaphase is not attempted until the sister chromatids of each chromosome are attached to spindle microtubules from opposite poles. The checkpoint mechanism involves a signal transduction cascade that is more complex than was originally envisioned.
Similar articles
-
Attachment and tension in the spindle assembly checkpoint.J Cell Sci. 2002 Sep 15;115(Pt 18):3547-55. doi: 10.1242/jcs.00029. J Cell Sci. 2002. PMID: 12186941 Review.
-
The yeast S phase checkpoint enables replicating chromosomes to bi-orient and restrain spindle extension during S phase distress.J Cell Biol. 2005 Mar 28;168(7):999-1012. doi: 10.1083/jcb.200412076. J Cell Biol. 2005. PMID: 15795314 Free PMC article.
-
Lack of tension at kinetochores activates the spindle checkpoint in budding yeast.Curr Biol. 2001 Sep 18;11(18):1462-7. doi: 10.1016/s0960-9822(01)00451-1. Curr Biol. 2001. PMID: 11566107
-
Regulation of APC-Cdc20 by the spindle checkpoint.Curr Opin Cell Biol. 2002 Dec;14(6):706-14. doi: 10.1016/s0955-0674(02)00382-4. Curr Opin Cell Biol. 2002. PMID: 12473343 Review.
-
The 'anaphase problem': how to disable the mitotic checkpoint when sisters split.Biochem Soc Trans. 2010 Dec;38(6):1660-6. doi: 10.1042/BST0381660. Biochem Soc Trans. 2010. PMID: 21118144 Review.
Cited by
-
The spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain.Genetics. 2001 Apr;157(4):1493-502. doi: 10.1093/genetics/157.4.1493. Genetics. 2001. PMID: 11290706 Free PMC article.
-
Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice.Proc Natl Acad Sci U S A. 2006 May 9;103(19):7339-44. doi: 10.1073/pnas.0510946103. Epub 2006 May 1. Proc Natl Acad Sci U S A. 2006. PMID: 16651529 Free PMC article.
-
Dynamic localization of the Swe1 regulator Hsl7 during the Saccharomyces cerevisiae cell cycle.Mol Biol Cell. 2001 Jun;12(6):1645-69. doi: 10.1091/mbc.12.6.1645. Mol Biol Cell. 2001. PMID: 11408575 Free PMC article.
-
MEKK1 is essential for DT40 cell apoptosis in response to microtubule disruption.Mol Cell Biol. 2001 Nov;21(21):7183-90. doi: 10.1128/MCB.21.21.7183-7190.2001. Mol Cell Biol. 2001. PMID: 11585901 Free PMC article.
-
A high proportion of genes involved in position effect variegation also affect chromosome inheritance.Chromosoma. 2004 Mar;112(6):269-76. doi: 10.1007/s00412-003-0272-2. Epub 2004 Feb 6. Chromosoma. 2004. PMID: 14767778 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
