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Review
. 2000 Feb;12(1):59-63.
doi: 10.1016/s0952-7915(99)00051-5.

The role of IL-18 in innate immunity

S Akira  1
Affiliations
Review

The role of IL-18 in innate immunity

S Akira. Curr Opin Immunol. 2000 Feb.

Abstract

IL-18 - a novel cytokine with potent IFN-gamma-inducing activities - plays an important role in the Th1-mediated immune response in collaboration with IL-12. IL-18 is a member of the IL-1 family. The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response.

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