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Review
. 2000 Feb;10(1):26-33.
doi: 10.1016/s0959-440x(99)00044-5.

Protein folding in vivo: the importance of molecular chaperones

D E Feldman  1 , J Frydman
Affiliations
Free article
Review

Protein folding in vivo: the importance of molecular chaperones

D E Feldman et al. Curr Opin Struct Biol. 2000 Feb.
Free article

Abstract

The contribution of the two major cytosolic chaperone systems, Hsp70 and the cylindrical chaperonins, to cellular protein folding has been clarified by a number of recent papers. These studies found that, in vivo, a significant fraction of newly synthesized polypeptides transit through these chaperone systems in both prokaryotic and eukaryotic cells. The identification and characterization of the cellular substrates of chaperones will be instrumental in understanding how proteins fold in vivo.

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