doi: 10.1212/wnl.54.3.729.
Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Canadian Collaborative Study Group
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- PMID: 10680811
- DOI: 10.1212/wnl.54.3.729
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Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Canadian Collaborative Study Group
Neurology.
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Abstract
The objective of this study was to investigate genes involved in the metabolism and function of vitamin D as candidate genes for genetic susceptibility to MS. Restriction fragment length polymorphisms and highly polymorphic microsatellite markers within or very close to the 1,25(OH)2D3 receptor (VDR) [12q14], the vitamin D binding protein (DBP) [4q12], and the 25(OH)D2 1alpha-hydroxylase [12q13] loci were analyzed for linkage or association with MS. We found no evidence for linkage or association of these candidate genes with MS in the Canadian population.
Comment in
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Seeking genes for MS: big risks for big gains.Neurology. 2000 Feb 8;54(3):542-4. doi: 10.1212/wnl.54.3.542. Neurology. 2000. PMID: 10680779 No abstract available.
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