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. 2000 Feb 8;54(3):743-6.
doi: 10.1212/wnl.54.3.743.

AIDS- and non-AIDS-related PML association with distinct p53 polymorphism

C Power  1 , J G Gladden, W Halliday, M R Del Bigio, A Nath, W Ni, E O Major, J Blanchard, M Mowat
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AIDS- and non-AIDS-related PML association with distinct p53 polymorphism

C Power et al. Neurology. .

Abstract

A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% among patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients. These findings indicate that frequencies of non-AIDS- and AIDS-related PML differ markedly but p53 polymorphisms may influence the occurrence of PML in both groups.

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