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. 2000 Mar;44(3):771-2.
doi: 10.1128/AAC.44.3.771-772.2000.

Pulsed ultrasound enhances the killing of Escherichia coli biofilms by aminoglycoside antibiotics in vivo

A M Rediske  1 , B L Roeder, J L Nelson, R L Robison, G B Schaalje, R A Robison, W G Pitt
Affiliations

Pulsed ultrasound enhances the killing of Escherichia coli biofilms by aminoglycoside antibiotics in vivo

A M Rediske et al. Antimicrob Agents Chemother. 2000 Mar.

Abstract

Escherichia coli biofilms on two polyethylene disks were implanted subcutaneously into rabbits receiving systemic gentamicin. Ultrasound was applied for 24 h to one disk. Both disks were removed, and viable bacteria were counted. Pulsed ultrasound significantly reduced bacterial viability below that of nontreated biofilms without damage to the skin.

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Figures

FIG. 1
FIG. 1
Comparison of log10 numbers of viable CFU from biofilm-coated polyethylene disks. The second bar from the right represents data from experiments in which ultrasound (US) at 300 mW/cm2 was pulsed in a 1:3 duty cycle, producing a time-averaged intensity of 100 mW/cm2. Likewise, the far right bar represents experiments in which ultrasound at 600 mW/cm2 was pulsed in a 1:6 duty cycle, also producing a time-averaged intensity of 100 mW/cm2. The asterisks indicate sets of data that are significantly different (P < 0.05) from data for implants treated with gentamicin only.
See this image and copyright information in PMC

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