Pulsed ultrasound enhances the killing of Escherichia coli biofilms by aminoglycoside antibiotics in vivo
- PMID: 10681355
- PMCID: PMC89763
- DOI: 10.1128/AAC.44.3.771-772.2000
Pulsed ultrasound enhances the killing of Escherichia coli biofilms by aminoglycoside antibiotics in vivo
Abstract
Escherichia coli biofilms on two polyethylene disks were implanted subcutaneously into rabbits receiving systemic gentamicin. Ultrasound was applied for 24 h to one disk. Both disks were removed, and viable bacteria were counted. Pulsed ultrasound significantly reduced bacterial viability below that of nontreated biofilms without damage to the skin.
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References
-
- Darouiche R O, Dhir A, Miller A J, Landon G C, Raad I I, Musher D M. Vancomycin penetration into biofilm covering infected prostheses and effect on bacteria. J Infect Dis. 1994;170:720–723. - PubMed
-
- Johnson L, Peterson R V, Pitt W G. Treatment of bacterial biofilms on polymeric implants using antibiotics and ultrasound. J Biomater Sci Polym Ed. 1998;9:1177–1185. - PubMed
-
- Khoury A E, Lam K, Ellis B, Costerton J W. Prevention and control of bacterial infections associated with medical devices. Am Soc Artif Intern Organs J. 1992;38:M174–M178. - PubMed
-
- Potera C. Biofilms invade microbiology. Science. 1996;273:1795–1797. - PubMed
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