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Clinical Trial
. 2000 Feb 12;355(9203):547-8.
doi: 10.1016/S0140-6736(99)05712-8.

Indinavir concentrations and St John's wort

S C Piscitelli, A H Burstein, D Chaitt, R M Alfaro, J Falloon
Clinical Trial

Indinavir concentrations and St John's wort

S C Piscitelli et al. Lancet. .

Erratum in

  • Lancet 2001 Apr 14;357(9263):1210

Abstract

St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.

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