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. 2000;14(2):70-2.
doi: 10.1002/(SICI)1098-2825(2000)14:2<70::AID-JCLA6>3.0.CO;2-M.

GB virus C in patients with liver disease of unknown etiology

E Quirós  1 , G Piédrola, C Maroto
Affiliations

GB virus C in patients with liver disease of unknown etiology

E Quirós et al. J Clin Lab Anal. 2000.

Abstract

To assess the prevalence of GBV-C in patients suffering unknown liver disease we have investigated the GBV-C-RNA in serum of 54 patients: 10 with acute and 32 with chronic non-A-E hepatitis (16 active and 16 persistent), 10 with hepatocellular carcinoma, 2 diagnosed with hepatic fulminant failure, and 91 healthy blood donors (control). PCR with primers from NS3 helicase region was performed and the product was identified by a double strand DNA enzyme immunoassay. GBV appears to infect 40 and 31% of acute or chronic non-A-E hepatitis respectively. Also the GBV genome was found in 1 in 10 samples of hepatocarcinoma, in 2 cases of fulminant hepatitis, and in 1 in 91 of the control group. In spite of these results the role of GBV in the etiology of liver diseases has to be analyzed in more comprehensive studies.

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