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. 1976 Oct;73(10):3719-22.
doi: 10.1073/pnas.73.10.3719.

Vitamin A-containing lipocytes and formation of type III collagen in liver injury

G Kent, S Gay, T Inouye, R Bahu, O T Minick, H Popper

Vitamin A-containing lipocytes and formation of type III collagen in liver injury

G Kent et al. Proc Natl Acad Sci U S A. 1976 Oct.

Abstract

Hepatocellular necrosis in carbon tetracholride-induced injury of rats is associated with an accumulation of lipocytes (perisinusoidal cells or Ito cells) containing fat droplets and giving vitamin A fluorescence. In the subsequent formation of connective tissue septa, transitional cells having morphologic characteristics of lipocytes and fibroblasts are abundant and are associated with the appearance of type III collage-. The features suggest that the lipocyte is the precursor of the fibroblasts responsible for parenchymal fibrillogenesis and under these conditions forms type III collagen. The process is a postulated link between hepatocellular necrosis and fibrosis.

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