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. 2000 Mar;14(2):99-102.
doi: 10.1002/(sici)1099-1573(200003)14:2<99::aid-ptr600>3.0.co;2-4.

Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats

E R Almeida  1 , A M Melo, H Xavier
Affiliations

Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats

E R Almeida et al. Phytother Res. 2000 Mar.

Abstract

The hydro-alcohol extract of the dry leaves of Peumus boldus and boldine, showed abortive and teratogenic action and changes in the blood levels of bilirubin, cholesterol, glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and urea in rats. The long term administration of the extract and boldine did not cause histological modification during a period of 90 days.

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