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Clinical Trial
. 2000 Feb;73(2):334-7.
doi: 10.1016/s0015-0282(99)00518-x.

Treatment of patients with long-standing unexplained subfertility with in vitro fertilization

P F Donderwinkel  1 , H van der Vaart, V M Wolters, A H Simons, G Kroon, M J Heineman
Affiliations
Free article
Clinical Trial

Treatment of patients with long-standing unexplained subfertility with in vitro fertilization

P F Donderwinkel et al. Fertil Steril. 2000 Feb.
Free article

Abstract

Objective: To evaluate whether IVF is an effective treatment for long-standing unexplained subfertility.

Design: Retrospective cohort study.

Setting: Tertiary care infertility center in a university hospital.

Patient(s): Two hundred two couples with unexplained subfertility of 2 years' duration or more who attended the center for their first IVF attempt.

Intervention(s): Couples were placed on a waiting list for IVF. They received no treatment until IVF was started.

Main outcome measure(s): Pregnancy rate (PR) while on the waiting list and PR after IVF treatment.

Result(s): Complete data sets were available for 131 couples. Seventeen of 131 women became pregnant while waiting for IVF treatment (PR 0.9% per exposure cycle), whereas 45 of 119 receiving IVF treatment became pregnant (PR 17% per IVF attempt).

Conclusion(s): IVF treatment has substantial added value over waiting and is an efficient treatment for long-standing unexplained subfertility.

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