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Comment
. 2000 Feb 25;287(5457):1500-3.
doi: 10.1126/science.287.5457.1500.

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

G C Perng  1 , C Jones, J Ciacci-Zanella, M Stone, G Henderson, A Yukht, S M Slanina, F M Hofman, H Ghiasi, A B Nesburn, S L Wechsler
Affiliations
Comment

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

G C Perng et al. Science. .

Abstract

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

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