Influence of autonomic tone on the filtered QRS duration from signal averaged electrocardiograms in healthy volunteers

Abstract

We recently reported that signal averaged electrocardiograms (SAECG) measurements possess a circadian rhythm and are closely related to heart rate or heart rate variability in healthy volunteers. This study determines the influence of autonomic tone on the filtered QRS (f-QRS) duration from SAECG by using pharmacologic autonomic blockade and exercise in healthy volunteers. Eleven healthy male volunteers were studied. Three protocols were designed to study the effects of exercise (Ex) under control conditions, beta adrenergic blockade or double blockade. SAECGs and heart rate variability (LF and HF: low and high frequency power, LF/HF ratio) were determined from Holter recordings. Ex significantly decreased the f-QRS duration and HF and significantly increased heart rate and LF/HF. Ex during beta adrenergic blockade significantly increased heart rate and decreased f-QRS duration and HF, but did not change LF/HF. Ex during double blockade did not affect the f-QRS duration, HF, or LF/HF. The changes in f-QRS duration induced during Ex, autonomic blockade, or both were inversely correlated with changes in heart rate and LF/HF and positively correlated with changes in HF. These data suggest that f-QRS duration in healthy subjects is shortened by Ex with increased sympathetic tone or decreased parasympathetic tone or the combination.