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Review
. 2000 Mar;119(3):383-9.
doi: 10.1046/j.1365-2249.2000.01192.x.

Early B cell defects

H B Gaspar  1 , M E Conley
Affiliations
Review

Early B cell defects

H B Gaspar et al. Clin Exp Immunol. 2000 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1
The stages of B lymphocyte development in the bone marrow and periphery are outlined. The most significant B cell developmental block most commonly seen in individuals with X-linked agammaglobulinaemia (XLA) is shown by a dashed line at the pro B cell to pre-B cell transition. However, there are also blocks at later stages as indicated by the dashed lines at the pre-B to immature B cell stage and at the immature to mature B lymphocyte stage. The knowledge from mouse studies and from individuals with congenital autosomal recessive agammaglobulinaemia has led to an understanding of the role of other genes in B cell development. The maturation arrest arising from abnormalities in these other genes is also demonstrated. A complete block at the pro to pre-B cell transition is seen in patients with μ heavy chain deficiency and in a patient with Igα deficiency.
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