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. 1976 Nov;73(11):4070-4.
doi: 10.1073/pnas.73.11.4070.

Tubulin requires tau for growth onto microtubule initiating sites

G B Witman, D W Cleveland, M D Weingarten, M W Kirschner

Tubulin requires tau for growth onto microtubule initiating sites

G B Witman et al. Proc Natl Acad Sci U S A. 1976 Nov.

Abstract

Tubulin purified by phosphocellulose chromatography and free of accessory proteins will not form microtubules in the absence or presence of microtubule initiating sites (flagellar microtubules). The capacity for growth onto pre-existing "seeds" can be restored by the addition of small quantities of partially purified tau protein. Larger quantities restore the capacity for spontaneous assembly. These results suggest that tubulin requires tau for both initiation and growth of microtubules and that tau is incorporated into the microtubule throughout its length.

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References

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