Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Nov;73(11):4159-63.
doi: 10.1073/pnas.73.11.4159.

Heat mutagenesis in bacteriophage T4: the transversion pathway

P M Bingham, R H Baltz, L S Ripley, J W Drake

Heat mutagenesis in bacteriophage T4: the transversion pathway

P M Bingham et al. Proc Natl Acad Sci U S A. 1976 Nov.

Abstract

Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.

PubMed Disclaimer

References

    1. Mol Gen Genet. 1975 Nov 3;141(1):23-40 - PubMed
    1. Proc Natl Acad Sci U S A. 1966 Apr;55(4):738-43 - PubMed
    1. J Am Chem Soc. 1970 Mar 25;92(6):1741-9 - PubMed
    1. J Virol. 1967 Apr;1(2):260-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1960 Jan;46(1):101-5 - PubMed

Publication types

Substances

LinkOut - more resources