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. 2000 Jan;129(2):231-4.
doi: 10.1038/sj.bjp.0703067.

Curcumin prevents adriamycin nephrotoxicity in rats

N Venkatesan  1 , D Punithavathi, V Arumugam
Affiliations

Curcumin prevents adriamycin nephrotoxicity in rats

N Venkatesan et al. Br J Pharmacol. 2000 Jan.

Abstract

The present study investigated the effect of curcumin on adriamycin (ADR) nephrosis in rats. The results indicate that ADR-induced kidney injury was remarkably prevented by treatment with curcumin. Treatment with curcumin markedly protected against ADR-induced proteinuria, albuminuria, hypoalbuminaemia and hyperlipidaemia. Similarly, curcumin inhibited ADR-induced increase in urinary excretion of N-acetyl-beta-D-glucosaminidase (a marker of renal tubular injury), fibronectin and glycosaminoglycan and plasma cholesterol. Curcumin restored renal function in ADR rats, as judged by the increase in GFR. The data also demonstrated that curcumin protected against ADR-induced renal injury by suppressing oxidative stress and increasing kidney glutathione content and glutathione peroxidase activity. In like manner, curcumin abolished ADR-stimulated kidney microsomal and mitochondrial lipid peroxidation. These data suggest that administration of curcumin is a promising approach in the treatment of nephrosis caused by ADR.

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Figures

Figure 1
Figure 1
Dose-dependent protective effect of curcumin against ADR-induced microsomal and mitochondrial lipid peroxidation. Microsomes or mitochondria were incubated with NADPH-generating system or NADH, respectively in the absence or presence of 100 μM ADR and lipid peroxidation was measured by the thiobarbituric acid method. Curcumin (1, 10 or 100 μM) was added to incubation mixtures before adding NADPH-generating system or NADH. Data are mean±s.d. of six observations. *Significantly (P<0.001) higher than all groups; †significantly (P<0.05) lower than ADR; ‡significantly (P<0.01) lower than ADR; ≈rcub;significantly (P<0.001) lower than ADR, but not significant compared to controls.
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