Review
doi: 10.1016/s0968-0004(99)01538-8.
The dynamin family of mechanoenzymes: pinching in new places
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- PMID: 10694881
- DOI: 10.1016/s0968-0004(99)01538-8
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Review
The dynamin family of mechanoenzymes: pinching in new places
Trends Biochem Sci.
2000 Mar.
Abstract
The large GTPase dynamin is a mechanoenzyme that mediates the liberation of nascent clathrin-coated pits from the plasma membrane during endocytosis. Recently, this enzyme has been demonstrated to comprise an extensive family of related proteins that have been implicated in a large variety of vesicle trafficking events during endocytosis, secretion and even maintenance of mitochondrial form. The potential contributions by the dynamin family to these diverse but related functions are discussed.
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