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Review
. 2000 Mar;25(3):115-20.
doi: 10.1016/s0968-0004(99)01538-8.

The dynamin family of mechanoenzymes: pinching in new places

M A McNiven  1 , H Cao, K R Pitts, Y Yoon
Affiliations
Review

The dynamin family of mechanoenzymes: pinching in new places

M A McNiven et al. Trends Biochem Sci. 2000 Mar.

Abstract

The large GTPase dynamin is a mechanoenzyme that mediates the liberation of nascent clathrin-coated pits from the plasma membrane during endocytosis. Recently, this enzyme has been demonstrated to comprise an extensive family of related proteins that have been implicated in a large variety of vesicle trafficking events during endocytosis, secretion and even maintenance of mitochondrial form. The potential contributions by the dynamin family to these diverse but related functions are discussed.

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