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Review
. 2000 Mar;25(3):121-6.
doi: 10.1016/s0968-0004(00)01551-6.

Histone deacetylases: silencers for hire

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Review

Histone deacetylases: silencers for hire

H H Ng et al. Trends Biochem Sci. 2000 Mar.

Abstract

Over the past few years, the long-standing idea that covalent modification of chromatin can play a role in determining states of gene activity has been confirmed. Eukaryotic genes can be silenced by deacetylation of acetyl-lysine moieties in the N-terminal tails of histones. Recent work links histone deacetylases with an increasing number of repressors, suggesting that deacetylation might be a rather pervasive feature of transcriptional repression systems.

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