Histone deacetylases: silencers for hire
- PMID: 10694882
- DOI: 10.1016/s0968-0004(00)01551-6
Histone deacetylases: silencers for hire
Abstract
Over the past few years, the long-standing idea that covalent modification of chromatin can play a role in determining states of gene activity has been confirmed. Eukaryotic genes can be silenced by deacetylation of acetyl-lysine moieties in the N-terminal tails of histones. Recent work links histone deacetylases with an increasing number of repressors, suggesting that deacetylation might be a rather pervasive feature of transcriptional repression systems.
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