Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Aug;52(4):169-73.
doi: 10.1136/mp.52.4.169.

The adenomatous polyposis coli protein

I S Näthke  1
Affiliations
Review

The adenomatous polyposis coli protein

I S Näthke. Mol Pathol. 1999 Aug.

Abstract

Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10596-601 - PubMed
    1. Genes Cells. 1998 Jun;3(6):395-403 - PubMed
    1. Mech Dev. 1998 Sep;77(1):75-80 - PubMed
    1. Curr Opin Cell Biol. 1998 Oct;10(5):629-39 - PubMed
    1. Curr Top Dev Biol. 1999;43:153-90 - PubMed

Publication types

MeSH terms

Substances