Case study 1: asbestos--the TLV approach
- PMID: 1069498
- DOI: 10.1111/j.1749-6632.1976.tb23104.x
Case study 1: asbestos--the TLV approach
Abstract
A review of the control of carcinogenic exposures using the TLV approach presents a prospect of limited effectiveness. With asbestos, as with any carcinogen, no threshold is known below which no health effect may be manifest. At best, we have only limited dose-response information at levels much above those of practical concern. In the case of asbestos, current exposures can only be described crudely at any level of exposure, and health effects are only known for past high, but ill-defined, exposures. Limited information exists on the effects of synergistic interactions with other materials. The current U.S. TLV, based on data concerned with occurrence of asbestosis, has not been evaluated with regard to possible effectiveness in the prevention of asbestos cancer. Yet cancer is the heart of the asbestos-hazard problem. Finally, enforcement of the existing TLV, especially for asbestos has been limited, frequently absent, and often ineffective. Workers are exposed in many situations to levels much above the current standard. As discouraging as this picture may seem, a TLV can be useful for stimulating the development and application of engineering-control procedures. The application of these procedures, however, must be specified and mandated in future standards to lower worker exposures to the minimum commensurate with existing technology. As technology is developed that makes lower exposure levels possible in a large part of the industry, TLVs should be reduced to take advantage of that technology.
Similar articles
-
Talc: a possible occupational and environmental carcinogen.J Occup Med. 1973 Feb;15(2):92-7. J Occup Med. 1973. PMID: 4685429 No abstract available.
-
Update of potency factors for asbestos-related lung cancer and mesothelioma.Crit Rev Toxicol. 2008;38 Suppl 1:1-47. doi: 10.1080/10408440802276167. Crit Rev Toxicol. 2008. PMID: 18671157
-
Cancer following occupational exposure to asbestos and vinyl chloride.Cancer. 1977 Apr;39(4 Suppl):1792-801. doi: 10.1002/1097-0142(197704)39:4+<1792::aid-cncr2820390808>3.0.co;2-j. Cancer. 1977. PMID: 322844 Review.
-
An evaluation of the risks of lung cancer and mesothelioma from exposure to amphibole cleavage fragments.Regul Toxicol Pharmacol. 2008 Oct;52(1 Suppl):S154-86. doi: 10.1016/j.yrtph.2007.09.020. Epub 2007 Oct 22. Regul Toxicol Pharmacol. 2008. PMID: 18396365 Review.
-
Lung cancer and mesothelioma among engine room crew--case reports with risk assessment of previous and ongoing exposure to carcinogens.Int Marit Health. 2007;58(1-4):5-13. Int Marit Health. 2007. PMID: 18350972
Cited by
-
Government laboratory worker with lung cancer: comparing risks from beryllium, asbestos, and tobacco smoke.Environ Health Perspect. 2000 Oct;108(10):1003-6. doi: 10.1289/ehp.001081003. Environ Health Perspect. 2000. PMID: 11049824 Free PMC article.
-
Airborne asbestos take-home exposures during handling of chrysotile-contaminated clothing following simulated full shift workplace exposures.J Expo Sci Environ Epidemiol. 2016 Jan-Feb;26(1):48-62. doi: 10.1038/jes.2015.15. Epub 2015 Apr 29. J Expo Sci Environ Epidemiol. 2016. PMID: 25921082
-
[Concept and usefulness of industrial hygiene].Soz Praventivmed. 1981 Jul;26(3):118-20. doi: 10.1007/BF02081366. Soz Praventivmed. 1981. PMID: 7293494 French. No abstract available.
-
Pulmonary fibrosis in asbestos insulation workers with lung cancer: a radiological and histopathological evaluation.Br J Ind Med. 1987 Feb;44(2):96-100. doi: 10.1136/oem.44.2.96. Br J Ind Med. 1987. PMID: 3814551 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous