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Review
. 2000 Apr;20(2):183-96.
doi: 10.1023/a:1007045605751.

The choroid plexuses and the barriers between the blood and the cerebrospinal fluid

M B Segal  1
Affiliations
Review

The choroid plexuses and the barriers between the blood and the cerebrospinal fluid

M B Segal. Cell Mol Neurobiol. 2000 Apr.

Abstract

1. The fluid homeostasis of the brain depends both on the endothelial blood-brain barrier and on the epithelial blood-cerebrospinal fluid (CSF) barrier located at the choroid plexuses and the outer arachnoid membrane. 2. The brain has two fluid environments: the brain interstitial fluid, which surrounds the neurons and glia, and the CSF, which fills the ventricles and external surfaces of the central nervous system. 3. CSF acts as a fluid cushion for the brain and as a drainage route for the waste products of cerebral metabolism. 4. Recent findings suggest that CSF may also act as a "third circulation" conveying substances secreted into the CSF rapidly to many brain regions.

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References

    1. Alm, A., and Bill, A. (1973). The effect of stimulation of the cervical sympathetic chain on retinal oxygen tension and on uveal, retinal and cerebral blood flow in cats. Acta Physiol. Scand.88:84-94. - PubMed
    1. Andres, K. H. (1967). Uber die Feinstruktur der Arachnoidea und Dura mater von Mammalia. Z. Zellforsch.79:272-295. - PubMed
    1. Bairamian, D., Johanson, C. E., Parmelee, J. T., and Epstein, M. H. (1991). Potassium cotransport with sodium and chloride in the choroid plexuses. J. Neurochem.56:1623-1629. - PubMed
    1. Bito, L. Z., Bradbury, M. W. B., and Davson, H. (1966). Factors affecting the distribution of iodide and bromide in the central nervous system. J. Physiol.185:323-354. - PMC - PubMed
    1. Bradley, R. D., and Semple, S. J. G. (1962). A comparison of certain acid base characteristics of arterial blood, jugular venous blood and cerebrospinal fluid in man, and the effect on them of some acute and chronic acid-base disturbances. J. Physiol.160:381-391. - PMC - PubMed

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