Review of intra-host models of malaria

Abstract

Intra-host models of malaria (and some related models of trypanosomiasis) are reviewed. A first section gives a short description of the different models, their purposes and the authors' conclusions. A second section discusses some common issues, including intra-host populations, the intra-host basic reproduction number (R0) and growth rates, density regulation mechanisms (including acquired immunity), and the models' behaviour compared to that of Plasmodium falciparum in man.