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Clinical Trial
. 2000 Mar;31(3):568-73.
doi: 10.1161/01.str.31.3.568.

Effects of stress reduction on carotid atherosclerosis in hypertensive African Americans

A Castillo-Richmond  1 , R H Schneider, C N Alexander, R Cook, H Myers, S Nidich, C Haney, M Rainforth, J Salerno
Affiliations
Clinical Trial

Effects of stress reduction on carotid atherosclerosis in hypertensive African Americans

A Castillo-Richmond et al. Stroke. 2000 Mar.

Abstract

Background and purpose: African Americans suffer disproportionately higher cardiovascular disease mortality rates than do whites. Psychosocial stress influences the development and progression of atherosclerosis. Carotid intima-media thickness (IMT) is a valid surrogate measure for coronary atherosclerosis, is a predictor of coronary outcomes and stroke, and is associated with psychosocial stress factors. Stress reduction with the Transcendental Meditation (TM) program decreases coronary heart disease risk factors and cardiovascular mortality in African Americans. B-mode ultrasound is useful for the noninvasive evaluation of carotid atherosclerosis.

Methods: This randomized controlled clinical trial evaluated the effects of the TM program on carotid IMT in hypertensive African American men and women, aged >20 years, over a 6- to 9-month period. From the initially enrolled 138 volunteers, 60 subjects completed pretest and posttest carotid IMT data. The assigned interventions were either the TM program or a health education group. By use of B-mode ultrasound, mean maximum IMT from 6 carotid segments was used to determine pretest and posttest IMT values. Regression analysis and ANCOVA were performed.

Results: Age and pretest IMT were found to be predictors of posttest IMT values and were used as covariates. The TM group showed a significant decrease of -0.098 mm (95% CI -0. 198 to 0.003 mm) compared with an increase of 0.054 mm (95% CI -0.05 to 0.158 mm) in the control group (P=0.038, 2-tailed).

Conclusions: Stress reduction with the TM program is associated with reduced carotid atherosclerosis compared with health education in hypertensive African Americans. Further research with this stress-reduction technique is warranted to confirm these preliminary findings.

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Figures

None
Comparative effects of TM and health education (HE) on carotid IMT in hypertensive African Americans. Graph shows mean change in IMT scores and 95% CI.
See this image and copyright information in PMC

References

    1. Keil JE, Sutherland SE, Knapp RG, Lackland DT, Gazes PC, Tyroler HA. Mortality rates and risk factors for coronary disease in black as compared with white men and women. N Engl J Med. 1993;329:73–78. - PubMed
    1. Cooper R, Ford E. Coronary heart disease among blacks and whites in the NHANES-1 Epidemiologic Follow-up Study: incidence of new events and risk factor prediction. Ann Epidemiol. 1992;2:637–645. - PubMed
    1. American Heart Association. 1997 Heart & Stroke Facts: Statistical Update. Dallas, Tex: American Heart Association; 1996.
    1. NHLBI. Report of the Working Group on Research in Coronary Heart Disease in Blacks. Washington, DC: National Institutes of Health, National Heart, Lung, and Blood Institute; 1994.
    1. NIH-National Heart, Lung, and Blood Institute. Morbidity and Mortality: 1996 Chartbook of Cardiovascular, Lung, and Blood Diseases. Washington, DC: National Institutes of Health; 1996.

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