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Review
. 2000 Mar;20(1):119-37.

The acute erythroleukemias

F M Mazzella  1 , C Alvares, A Kowal-Vern, H R Schumacher
Affiliations
  • PMID: 10702900
Review

The acute erythroleukemias

F M Mazzella et al. Clin Lab Med. 2000 Mar.

Abstract

Acute erythroleukemia is an aggressive leukemia derived from a multipotential stem cell. Three subtypes have been described: (1) M6a with greater than or equal to 30% blasts of the nonerythrocytic component, (2) M6b with greater than or equal to 30% pronormoblasts of the erythrocytic elements, and (3) M6c with greater than or equal to 30% blasts and greater than or equal to 30% pronormoblasts by the aforementioned exclusion criteria. The poor prognosis associated with this disorder positively correlates with a high pronormoblast:myeloblast ratio; unfavorable cytogenetic aberrations; a high proliferative index; and the presence of P-glycoprotein expression (multidrug resistance phenotype). Chemotherapeutic regimens directed toward these specific parameters should be devised in order to improve the characteristically poor outcome of this patient population.

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