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Review
. 2000 Mar 6;148(5):843-8.
doi: 10.1083/jcb.148.5.843.

Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators

S N Prokopenko  1 , R Saint, H J Bellen
Affiliations
Review

Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators

S N Prokopenko et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
The basics of cytokinesis. Cytokinesis is accomplished through progression of a cleavage furrow (invaginations of a de novo added plasma membrane in green) which divides a cell into two daughter cells. The driving force of this constriction is an actomyosin contractile ring (red) which forms at the cell equator in late anaphase. The positioning of a cleavage plane is thought to depend on a central spindle (blue) and, possibly, spindle poles (i.e., mitotic apparatus). Cytokinesis results in distribution of chromosomes (nuclei in pink) and cytoplasm with organelles (yellow) between daughter cells, thus completing the mitotic cycle.
Figure 2
Figure 2
Rho-mediated signal transduction pathways operating during cytokinesis. Positive regulators or active proteins are shown in green. Negative regulators or inactive proteins are shown in red. Specific examples are listed in curly brackets. Although the existence of a Rho•GTP/FH protein–mediated pathway initiating actin polymerization during cytokinesis has been demonstrated, the role of ROCK-like kinases in assembly of myosin filaments during cytokinesis is presumed, based on their known roles in other actin-dependent processes. The assembly of actin and myosin filaments (together with septins and actin-interacting proteins) into a contractile ring and the regulation of actomyosin contractility during cytokinesis are even more poorly understood. Abbreviations: F-actin, fibrous actin; FH-protein, formin homology protein; G-actin, globular actin; GFAP, glial fibrillary acidic protein; IFs, intermediate filaments; P, phosphorylation. For other abbreviations and for details see text.
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