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. 2000 Feb;66(1):82-3.
doi: 10.1055/s-0029-1243117.

Antihyperglycemic acetylenic glucosides from Bidens pilosa

R P Ubillas, C D Mendez, S D Jolad, J Luo, S R King, T J Carlson, D M Fort

Antihyperglycemic acetylenic glucosides from Bidens pilosa

R P Ubillas et al. Planta Med. 2000 Feb.

Abstract

In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C57 BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyacetylenic glucosides, identified as 2-beta-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-+ ++triyne (1) and 3-beta-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,1 2-triyne (2). A 3:2 mixture of compounds 1 and 2 effected a significant drop in blood glucose.

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