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. 2000 Mar;2(3):173-7.
doi: 10.1038/35004052.

Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels

I Dzhura  1 , Y Wu, R J Colbran, J R Balser, M E Anderson
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Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels

I Dzhura et al. Nat Cell Biol. 2000 Mar.

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Abstract

A dynamic positive feedback mechanism, known as 'facilitation', augments L-type calcium-ion currents (ICa) in response to increased intracellular Ca2+ concentrations. The Ca2+-binding protein calmodulin (CaM) has been implicated in facilitation, but the single-channel signature and the signalling events underlying Ca2+/CaM-dependent facilitation are unknown. Here we show that the Ca2+/CaM-dependent protein kinase II (CaMK) is necessary and possibly sufficient for ICa facilitation. CaMK induces a channel-gating mode that is characterized by frequent, long openings of L-type Ca2+ channels. We conclude that CaMK-mediated phosphorylation is an essential signalling event in triggering Ca2+/CaM-dependent ICa facilitation.

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  • Findings of research misconduct.
    [No authors listed] [No authors listed] NIH Guide Grants Contracts (Bethesda). 2014 Dec 5:NOT-OD-15-031. NIH Guide Grants Contracts (Bethesda). 2014. PMID: 25528784 Free PMC article. No abstract available.

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