[Insulin resistance and liver]

Abstract

The liver plays an important role in glucose homeostasis. In the postabsorptive state, plasma glucose is regulated by both hepatic glucose output(HGO) and peripheral glucose utilization(PGU). Insulin and glucagon regulate both HGO and PGU. Increased HGO and decreased PGU, suggesting insulin resistances bring increased fasting blood glucose. While glucose homeostasis after glucose ingestion is regulated by several factors. The regulation of hepatic glucose uptake(HGU) occurs by way of the hormonal milieu(insulin and glucagon), the glucose level, and the rote of glucose delivery. The presence of coordinated changes in insulin, glucagon and the glucose level in combination with the portal signal ensures adequate HGU in response to liver. Hepatic insulin resistance(increased HGO and decreased HGU) and peripheral insulin resistance(decreased PGU) are the characters of glucose intolerance.