Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Apr;12(2):217-21.
doi: 10.1016/s0955-0674(99)00085-x.

A-kinase anchoring proteins: protein kinase A and beyond

A S Edwards  1 , J D Scott
Affiliations
Review

A-kinase anchoring proteins: protein kinase A and beyond

A S Edwards et al. Curr Opin Cell Biol. 2000 Apr.

Abstract

Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of the functional consequences of PKA anchoring.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources