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Review
. 2000 Apr;12(2):235-43.
doi: 10.1016/s0955-0674(99)00081-2.

Smads as transcriptional co-modulators

L Attisano  1 , J L Wrana
Affiliations
Review

Smads as transcriptional co-modulators

L Attisano et al. Curr Opin Cell Biol. 2000 Apr.

Abstract

The Smad signalling pathway is critical for transmitting transforming growth factor-beta (TGF-beta) superfamily signals from the cell surface to the nucleus. In the nucleus, Smads regulate transcriptional responses by recruiting co-activators and co-repressors to a wide array of DNA-binding partners. Thus, Smads function as transcriptional co-modulators to regulate TGFbeta-dependent gene expression.

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