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. 2000 May 1;104(2):109-15.
doi: 10.1016/s0165-5728(99)00262-3.

PU.1 expression in microglia

M R Walton  1 , H Gibbons, G A MacGibbon, E Sirimanne, J Saura, P D Gluckman, M Dragunow
Affiliations

PU.1 expression in microglia

M R Walton et al. J Neuroimmunol. .

Abstract

The transcription factor PU.1 has a pivotal role in both the generation and function of macrophages. To determine whether PU.1 is also involved in microglial regulation, we investigated its expression following hypoxic-ischemia (HI) brain injury and in the BV-2 microglial cell line. We found that microglia constitutively expressed high levels of PU.1 protein in both their 'resting' and 'activated' states.

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