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. 2000 Mar 15;184(2):285-9.
doi: 10.1111/j.1574-6968.2000.tb09028.x.

Genetic analysis of SecA-SecY interaction required for spore development in Bacillus subtilis

H Kobayashi  1 , Y Ohashi, H Nanamiya, K Asai, F Kawamura
Affiliations

Genetic analysis of SecA-SecY interaction required for spore development in Bacillus subtilis

H Kobayashi et al. FEMS Microbiol Lett. .

Abstract

All spontaneous suppressor mutations obtained from a secA12 sporulation-defective mutant in Bacillus subtilis were localized in highly conserved membrane-spanning regions of SecY. The expression of early sporulation genes, kinA and spo0A encoding a histidine kinase and a transcription regulator for several sporulation genes, respectively, was restored in these suppressor mutants. These results indicate that the secretion function of translocase combined with Sec proteins is required for sporulation in B. subtilis.

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