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Clinical Trial
. 2000 Jan;15(1):25-31.
doi: 10.3904/kjim.2000.15.1.25.

The influence of gastrectomy on the change of bone metabolism and bone density

S J Kwon  1 , J S Hahm, Y J Cho, Y Ahn, D I Shin
Affiliations
Clinical Trial

The influence of gastrectomy on the change of bone metabolism and bone density

S J Kwon et al. Korean J Intern Med. 2000 Jan.

Abstract

Objectives: Abnormalities of bone metabolism could be followed in gastrectomized patients as a late complication. Nowadays, many biochemical and radiologic measurements are applied to detect these abnormalities. The aim of our study is to determine the valuable parameter as an appropriate screening test during long-term follow-up periods and define the usefulness of new biochemical markers for bone metabolism by comparing with traditional markers.

Methods: Fifteen patients who had undergone partial gastrectomy were chosen randomly and fifteen healthy controls were compared. Then, several biochemical and radiologic tests were measured. We excluded subjects who proved to have other causes of bone metabolism abnormalities. Ten patients and 10 controls were finally selected.

Results: Comparing the data with those of a corresponding control group, the lumbar bone density measured by quantitative computed tomography (QCT) was statistically significantly lower in the patient group (p < 0.01). The urinary deoxypyridinoline, a biochemical marker for bone resorption, was statistically higher in the patient group (p < 0.025). Osteocalcin, Procollagen I C-terminal peptide (PICP) and Type I collagen C-terminal telopeptide (ICTP) were slightly but not significantly higher in the patient group. The serum parathyroid hormone (PTH) and 25-hydroxy vitamin D levels were similar in both groups.

Conclusion: We could suggest that urinary deoxypyridinoline and QCT are appropriate parameters as screening tests for the detection of bone metabolism abnormalities in gastrectomized patients during long-term follow-up. Urinary deoxypyridinoline may be a simple and rapid test which could replace cumbersome 24-hour urinary hydroxyproline.

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Figures

Figure 1.
Figure 1.
Bone mineral density in patients and controls. Horizontal bar; mean values.
Figure 2.
Figure 2.
Urinary DPD in patients and controls. Horizontal bar; mean values
Figure 3.
Figure 3.
Serum Osteocalcin levels in patients and controls Horizontal bar; mean values.
Fig. 4.
Fig. 4.
Serum PICP levels in patients and controls. Horizontal bar; mean values
Figure 5.
Figure 5.
Serum ICTP levels in patients and controls. Horizontal bar; mean values.
See this image and copyright information in PMC

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