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Case Reports
. 2000 Apr;46(4):574-7.
doi: 10.1136/gut.46.4.574.

Intramucosal adenocarcinoma arising under squamous re-epithelialisation of Barrett's oesophagus

J L Van Laethem  1 , M O Peny, I Salmon, M Cremer, J Devière
Affiliations
Case Reports

Intramucosal adenocarcinoma arising under squamous re-epithelialisation of Barrett's oesophagus

J L Van Laethem et al. Gut. 2000 Apr.

Abstract

Background: Eradication of Barrett's mucosa by thermal or photoablation combined with high doses of proton pump inhibitors is a potentially attractive strategy in the management of this preneoplastic condition. However, major concerns of this method are the persistence of residual metaplastic glands beneath the new squamous epithelium and the absence of any knowledge of its impact on long term outcome.

Case report: The case of an intramucosal adenocarcinoma diagnosed 18 months after apparently complete squamous re-epithelialisation achieved using argon plasma coagulation and high dose omeprazole (40 mg/daily) is reported in a 68 year old patient presenting initially with a Barrett's oesophagus without dysplasia. Intramucosal adenocarcinoma was located under the new squamous layer and presented as a bulging area covered by the squamous epithelium. It probably originates from residual metaplastic glands after therapy although a pre-existing tumour cannot be definitely excluded.

Conclusion: This observation might question future application of this experimental endotherapy in non-dysplastic Barrett's oesophagus. It suggests that the residual glands might still be premalignant and that the early diagnosis of neoplastic changes might be compromised by the squamous re-epithelialisation.

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Figures

Figure 1
Figure 1
Endoscopic view of the lower part of the re-epithelialised Barrett's mucosa after four argon plasma coagulation sessions.
Figure 2
Figure 2
Residual metaplastic glands are found beneath the new squamous epithelium after completion of endoscopic treatment.
Figure 3
Figure 3
Eighteen months after complete apparent re-epithelialisation, mucosal bulging (arrowheads) was observed just above the new squamocolumnar junction.
Figure 4
Figure 4
Histology showed a specialised columnar epithelium with high grade dysplasia below a thin surface squamous layer clearly attached to the dysplastic glands (arrow).
Figure 5
Figure 5
Part of the histological view of the mucosectomy specimen confirming the presence of an intramucosal carcinoma.
See this image and copyright information in PMC

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