Review
doi: 10.1016/s0924-8579(99)00145-4.
Antibiotic efficacy in vivo predicted by in vitro activity
Affiliations
- PMID: 10720797
- DOI: 10.1016/s0924-8579(99)00145-4
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Review
Antibiotic efficacy in vivo predicted by in vitro activity
Int J Antimicrob Agents.
2000 Mar.
Abstract
A brief overview of arguments found in the literature is presented to apply the E(max) concept to experimental studies of antibiotics as well as to their clinical application. It may turn out to be more flexible than schedules based on arbitrary parameters that have the disadvantage that they have to be proven in each individual situation.
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