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. 2000 Apr;44(4):1075-7.
doi: 10.1128/AAC.44.4.1075-1077.2000.

Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis

M Heep  1 , U Rieger, D Beck, N Lehn
Affiliations

Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis

M Heep et al. Antimicrob Agents Chemother. 2000 Apr.

Abstract

A clinical isolate of Helicobacter pylori that developed resistance to rifabutin during therapy carried an rpoB gene that retained a wild-type cluster region sequence but had acquired a novel codon 149 (V149F) mutation. In transformation experiments, the mutation was shown to confer high-level rifabutin resistance. The equivalent mutation (V176F) was present in several resistant isolates of Mycobacterium tuberculosis.

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Figures

FIG. 1
FIG. 1
Alignment of the homologous amino acid sequences of the N-terminal region of RpoB of different species. The figure shows mapping of codons associated with the rifamycin resistance phenotype (boxes).
See this image and copyright information in PMC

References

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